Guerra 20_9
ثبت نشده
چکیده
Protein kinase CK2 is a highly conserved serine/ threonine kinase ubiquitously distributed in all investigated eukaryotes and involved in several intracellular pathways which control, among others, cell cycle, proliferation, apoptosis and transformation. Similarly, the PI3K-AKT pathway deregulation has been shown to play an important role in tumor development and tumor response to anti-cancer treatment. In this study, it is shown that the specific inhibition of the PI3KAKT signaling pathway in combination with depletion of CK2 subunits by antisense oligodeoxynucleotides leads to an enhanced drug-induced apoptotic response. Moreover, in vitro as well as in vivo studies show that the individual CK2 subunits interact with AKT kinase and that the complex formation is not modulated by the phosphorylation status of AKT. Furthermore, the fact that the interaction between CK2 subunits and AKT enhances AKT kinase activity identifies a novel molecular mechanism that leads to modulation of AKT activation raising the possibility that CK2 and AKT might be implicated in common pathways that control cell proliferation and survival.
منابع مشابه
Economics of Trust in the Information Economy: Issues of Identity, Privacy and Security
* This paper has been jointly prepared for the Organisation for Economic Co-operation and Development (OECD) by the BREB and OII of the University of Oxford. The lead role was taken by Gerardo A. Guerra, who wrote the first draft. The final version was revised and edited by William Dutton and Malcolm Peltu, based on input from Ann Carblanc, Graham Vickery, Francis Aldhouse, Gerardo Guerra and D...
متن کاملParvovirus in Human Cells Gene Restrict the Host Range of a Murine Functions Mapping to the Nonstructural Genome Replication and Postencapsidation
متن کامل
The Cognitive- Ecological Model Paradigm and Promise for the Future
Recent advances in research and practice on the prevention and treatment of youth mental health problems have emphasized the central role of the child's developing cognitions (Boxer & Dubow, 2002; Compton et ai., 2004; Guerra, Boxer, & Kim, 2005). Children actively participate in a variety of contexts (e.g., home, neighborhood, school) that provide the settings and experiences that shape their ...
متن کاملBoundary conditions for the P()2 euclidean field theory
Boundary conditions for the P(φ) 2 euclidean field theory Annales de l'I. Article numérisé dans le cadre du programme Numérisation de documents anciens mathématiques
متن کامل